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38030-57-8

38030-57-8 structure
38030-57-8 structure
  • Name: all-trans-4-Oxoretinoic acid
  • Chemical Name: all-trans-4-oxoretinoic acid
  • CAS Number: 38030-57-8
  • Molecular Formula: C20H26O3
  • Molecular Weight: 314.41900
  • Catalog: Natural Products Others
  • Create Date: 2018-02-10 08:00:00
  • Modify Date: 2024-01-02 18:07:07
  • all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
Name all-trans-4-oxoretinoic acid
Synonyms 4-keto-Retinoic Acid
4-oxo-all-rans-retinoic acid
4-Oxoretinoic Acid
all-trans-4-Oxoretinoic Acid
4-oxo-all-trans-retinoic acid
all-trans 4-Keto Retinoic Acid
4-oxo-Retinoic acid
4-Ketoretinoic Acid
4-Oxo-atRA
4-Oxotretinoin
Description all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
Related Catalog
Target

Human Endogenous Metabolite
In Vitro all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs)[1]. all-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid (RA) [2].
References

[1]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.

[2]. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.
Density 1.07g/cm3
Boiling Point 509.9ºC at 760 mmHg
Melting Point 175-178°C (分解)
Molecular Formula C20H26O3
Molecular Weight 314.41900
Flash Point 276.3ºC
Exact Mass 314.18800
PSA 54.37000
LogP 4.78160
Index of Refraction 1.565
Storage condition 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6599800
CHEMICAL NAME :
Retinoic acid, 4-oxo-
CAS REGISTRY NUMBER :
38030-57-8
LAST UPDATED :
199007
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C20-H26-O3
MOLECULAR WEIGHT :
314.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,33A,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 100,162,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
39 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4900 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988
71748-57-7 structure

71748-57-7

~87%

38030-57-8 structure

38030-57-8
Literature: Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493
38030-59-0 structure

38030-59-0

~%

38030-57-8 structure

38030-57-8
Literature: Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
81121-19-9 structure

81121-19-9

~%

38030-57-8 structure

38030-57-8
Literature: Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
72526-76-2 structure

72526-76-2

~%

38030-57-8 structure

38030-57-8
Literature: Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
63184-93-0 structure

63184-93-0

~%

38030-57-8 structure

38030-57-8
Literature: Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
302-79-4 structure

302-79-4

~%

38030-57-8 structure

38030-57-8

66592-72-1 structure

66592-72-1
Literature: UNIVERSITY OF WASHINGTON Patent: US2008/249042 A1, 2008 ; Location in patent: Page/Page column 2; 27; 29; 31; Sheet 14/24; 24/24 ;
33532-44-4 structure

33532-44-4

~%

38030-57-8 structure

38030-57-8
Literature: Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493
62054-49-3 structure

62054-49-3
63184-93-0 structure

63184-93-0

~%

38030-57-8 structure

38030-57-8
Literature: Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
81121-21-3 structure

81121-21-3

~%

38030-57-8 structure

38030-57-8

66592-72-1 structure

66592-72-1
Literature: Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430

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title: CAS No. 38030-57-8 | Chemsrc address: https://www.chemsrc.com/en/baike/600197.html

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