35890-38-1

35890-38-1 structure

Name: 3'-sialyllactose
Chemical Name: (2S,4S,5R,6R)-5-acetamido-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
CAS Number: 35890-38-1
Molecular Formula: C₂₃H₃₉NO₁₉
Molecular Weight: 633.55100
Catalog: Biochemical Carbohydrate Double sugar
Create Date: 2018-09-04 23:02:13
Modify Date: 2025-08-24 08:28:13
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2].

Name	(2S,4S,5R,6R)-5-acetamido-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Synonyms	N-acetylneuraminoyllactose 3'-Sialyllactose 3'-sialyllactose 3'-Sialyllactose (3'-SL) 32-N-Acetyl-a-neuraminyllactose 3'-N-Acetylneuraminyl-D-lactose 3'-Monosialyllactose 3'-a-Sialyllactose N-acetylneuraminosyl-D-lactose 3'-Sialyl-D-lactose a2,3-Sialyllactose

Description	3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. Western Blot Analysis[1] Cell Line: Chondrocytes Concentration: 0, 50, 100 and 250 μM Incubation Time: 24-36 hours Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3,Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
In Vivo	3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1] Dosage: 10, 50 and 100 mg/kg Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
References	[1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66. [2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603.

Density	1.72 g/cm3
Boiling Point	1132.8ºC at 760 mmHg
Molecular Formula	C₂₃H₃₉NO₁₉
Molecular Weight	633.55100
Flash Point	638.9ºC
Exact Mass	633.21200
PSA	342.92000
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	B
RIDADR	NONH for all modes of transport
WGK Germany	3

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