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Shanghai Jizhi Biochemical Technology Co., Ltd
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Product Name: Caryophyllene oxide
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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: b-Caryophyllene oxide
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1139-30-6

1139-30-6 structure

1139-30-6 structure

Name: Caryophyllene oxide
Chemical Name: (-)-Caryophyllene oxide
CAS Number: 1139-30-6
Molecular Formula: C₁₅H₂₄O
Molecular Weight: 220.350
Catalog: Flavors and spices Synthetic spice Phenols, ethers and epoxides Epoxide
Create Date: 2018-10-01 11:05:16
Modify Date: 2024-01-01 20:07:51
Caryophyllene oxide, isolated from from Annona squamosa L. bark., possesses analgesic and anti-inflammatory activity[1].

Name	(-)-Caryophyllene oxide
Synonyms	(1R,4R,6R,10S)-4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane (-)-b-Caryophyllene oxide 6,7-Epoxy-3(15)-caryophyllene (−)-Caryophyllene oxide 4b,5a-Epoxycaryophyllene (-)-b-Caryophyllene epoxide (1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.0]dodecane (-)-Epoxydihydrocaryophyllene (-)-caryophyllene oxide 5-Oxatricyclo(8.2.0.0(4,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)- b-Caryophyllene oxide Caryophyllene 4b,5a-oxide β-Caryophyllene oxide EINECS 214-519-7 MFCD00134216 b-Caryophyllene epoxide trans-caryophyllene oxide 5-Oxatricyclo[8.2.0.0]dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)- caryophyllene oxide (−)-Epoxycaryophyllene

Description	Caryophyllene oxide, isolated from from Annona squamosa L. bark., possesses analgesic and anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Chavan MJ, et al. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine. 2010 Feb;17(2):149-51.

Density	1.0±0.1 g/cm3
Boiling Point	279.7±19.0 °C at 760 mmHg
Melting Point	62-63ºC(lit.)
Molecular Formula	C₁₅H₂₄O
Molecular Weight	220.350
Flash Point	119.7±19.5 °C
Exact Mass	220.182709
PSA	12.53000
LogP	4.57
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.507

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5530000

CHEMICAL NAME :: 5-Oxatricyclo(8.2.0.0(sup 4,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

CAS REGISTRY NUMBER :: 1139-30-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24-O

MOLECULAR WEIGHT :: 220.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	RP5530000
HS Code	29109000

87-44-5 structure

87-44-5

~%

1139-30-6 structure

1139-30-6

103475-43-0 structure

103475-43-0

Literature: Helvetica Chimica Acta, , vol. 77, # 1 p. 36 - 40

87-44-5 structure

87-44-5

~%

1139-30-6 structure

1139-30-6

Literature: Helvetica Chimica Acta, , vol. 66, # 7 p. 2223 - 2235

93-59-4 structure

93-59-4

87-44-5 structure

87-44-5

~%

1139-30-6 structure

1139-30-6

Literature: Chemische Berichte, , vol. 80, p. 56,62 Journal of the Chemical Society, , p. 537,539

2311-91-3 structure

2311-91-3

87-44-5 structure

87-44-5

~%

1139-30-6 structure

1139-30-6

Literature: Journal of the Chemical Society, , p. 4336,4339

87-44-5 structure

87-44-5

~53%

1139-30-6 structure

1139-30-6

60444-80-6 structure

60444-80-6

60479-10-9 structure

60479-10-9

Literature: Bulletin de la Societe Chimique de France, , vol. 132, # 8 p. 836 - 842

87-44-5 structure

87-44-5

~%

118122-82-0 structure

118122-82-0

108525-13-9 structure

108525-13-9

73510-14-2 structure

73510-14-2

Detail

Literature: Phytochemistry (Elsevier), , vol. 29, # 1 p. 115 - 120

Precursor 3
87-44-5 93-59-4 2311-91-3
DownStream 1
32214-91-8