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480-20-6

480-20-6 structure
480-20-6 structure
  • Name: Aromadendrin
  • Chemical Name: (+)-dihydrokaempferol
  • CAS Number: 480-20-6
  • Molecular Formula: C15H12O6
  • Molecular Weight: 288.252
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-05-12 08:00:00
  • Modify Date: 2025-08-26 13:35:46
  • Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].
Name (+)-dihydrokaempferol
Synonyms 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R-trans)-
Katuranin
(2R,3R)-3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(+)-dihydrokaempferol
Aromadedrin
Aromadendrin
4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)-
DIHYDROKAEMPFEROL
Description Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].
Related Catalog
Target

Apoptosis; Bcl-2; Bcl-xL[1]

In Vitro Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1]. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1]. Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.
References

[1]. Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160.
Density 1.6±0.1 g/cm3
Boiling Point 639.0±55.0 °C at 760 mmHg
Molecular Formula C15H12O6
Molecular Weight 288.252
Flash Point 247.3±25.0 °C
Exact Mass 288.063385
PSA 107.22000
LogP 2.42
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.729
Storage condition ?20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P273-P501
Hazard Codes N,Xn
Risk Phrases 50-22
Safety Phrases 61
RIDADR UN 3077 9 / PGIII
6515-21-5 structure

6515-21-5

~%

480-20-6 structure

480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377
65490-09-7 structure

65490-09-7

~%

480-20-6 structure

480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377
36804-11-2 structure

36804-11-2

~%

480-20-6 structure

480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377
118160-11-5 structure

118160-11-5

~%

480-20-6 structure

480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377
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