Name | Zonisamide sodium salt |
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Synonyms |
sodium,1,2-benzoxazol-3-ylmethylsulfonylazanide
Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide 1,2-Benzisoxazole-3-methanesulfonamide, sodium salt (1:1) Zonisamide (sodium) |
Description | Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.Target: Calcium channel inhibitor; Sodium channel inhibitorZonisamide sodium is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure. Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification it appears to block the propagation/spread of seizure discharges and to suppress the epileptogenic focus [1].Zonisamide sodium 500 mg/day was significantly superior to placebo in reducing the frequency of complex partial seizures (-51% versus -16%), all partial seizures and all seizures, with dose-dependent benefit provided over a 100-500 mg/day dose range. Supporting trials have confirmed significant increases in reduction in median seizure frequency (up to 41%) and responder rates (35-42%) compared with placebo following zonisamide sodium 400-600 mg/day, enabling 20-27% of patients to attain >or=75% reduction in seizure frequency [2].Clinical indications: Epilepsy; Lewy body dementia; Parkinsons diseaseToxicity: Anorexia; Somnolence; Dizziness; Irritability; Confusional state; Depression; Diplopia; Memory impairment |
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Related Catalog | |
References |
Boiling Point | 457.2ºC at 760 mmHg |
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Molecular Formula | C8H7N2NaO3S |
Molecular Weight | 234.208 |
Exact Mass | 234.007507 |
PSA | 80.58000 |
LogP | 2.18320 |
Storage condition | 2-8℃ |