Name | ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate |
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Synonyms |
Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
Tocriscreen Total |
Description | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)[1]. Ro15-4513 is a potent ethanol antagonist[2]. Ro15-4513 has anti-anxiety effect[3]. |
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Related Catalog | |
Target |
BZR[1]; ethanol[2]; |
In Vitro | Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors, except an agonist for α4 and α6 subunit-containing ones[3]. |
In Vivo | Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing[2]. Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice[2]. Animal Model: Male C57BL/6J mice[2] Dosage: 3 mg/kg Administration: I.p.; 10 min before being tested Result: Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing. |
References |
Molecular Formula | C15H14N6O3 |
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Molecular Weight | 326.31000 |
Exact Mass | 326.11300 |
PSA | 114.18000 |
LogP | 1.96706 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |