125464-42-8
125464-42-8 structure
- Name: Saclofen
- Chemical Name: 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid
- CAS Number: 125464-42-8
- Molecular Formula: C9H12ClNO3S
- Molecular Weight: 249.714
- Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
- Create Date: 2018-12-20 16:01:17
- Modify Date: 2025-08-20 06:52:22
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Saclofen is a competitive antagonist of the GABAB receptor with an IC50 of 7.8 μM. Saclofen can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain[1].
| Name | 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid |
|---|---|
| Synonyms |
Saclofen
3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid UNII:LRZ36BCQ1Y Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro- MFCD00216817 3-Amino-2-(4-chlorophenyl)-1-propanesulfonic acid beta-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid |
| Description | Saclofen is a competitive antagonist of the GABAB receptor with an IC50 of 7.8 μM. Saclofen can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.437±0.06 g/cm3 |
|---|---|
| Melting Point | 310-315 ºC |
| Molecular Formula | C9H12ClNO3S |
| Molecular Weight | 249.714 |
| Exact Mass | 249.022644 |
| PSA | 88.77000 |
| LogP | 0.03 |
| Index of Refraction | 1.600 |
| Storage condition | Store at RT |
| Water Solubility | Slightly soluble (7.5 g/L) (25 ºC) |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921499090 |
|
~58%
125464-42-8 |
| Literature: Li; Howson; Dolle Synthesis, 1991 , # 3 p. 244 - 244 |
|
~%
125464-42-8 |
| Literature: Synthesis, , # 3 p. 244 - 244 |
|
~%
125464-42-8 |
| Literature: Synthesis, , # 3 p. 244 - 244 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| HS Code | 2921499090 |
|---|---|
| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |