Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pseudourea, 2-ethyl-2-thio-, hydrobromide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2-ethylisothiourea hydrobromide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

1071-37-0

1071-37-0 structure

Name: Ethyl carbamimidothioate hydrobromide (1:1)
Chemical Name: ethyl carbamimidothioate,hydrobromide
CAS Number: 1071-37-0
Molecular Formula: C₃H₉BrN₂S
Molecular Weight: 185.09
Catalog: Chemical reagent Organic reagent Thiourea
Create Date: 2018-06-27 18:24:43
Modify Date: 2024-01-08 23:19:36
S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Name	ethyl carbamimidothioate,hydrobromide
Synonyms	MFCD00012585 Ethiron S-ethylisothiouronium hydrobromate S-Ethylisothio Urea,Hydrobromide Ethyl carbamimidothioate hydrobromide (1:1) Ethiron bromide USAF EL-18 S-ethylthiouronium bromide 2-Ethyl-2-isothiourea hydrobromide S-Ethylisothiuronium bromide S-Ethylthiuronium bromide 2-Ethyl-2-thiopseudourea hydrobromide 2-ethyl isothiourea hydrobromide Carbamimidothioic acid, ethyl ester, hydrobromide (1:1) Bromide S-ethylisothiuronium etiron S-Ethylisothiouronium hydrobromide ethyl imidothiocarbamate hydrobromide S-ETHYLISOTHIOUREA HYDROBROMIDE

Description	S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others
In Vitro	EIT (S-ethylisothiourea) Hydrobromide 是 II 型 NOS 的选择性抑制剂。EIT 对 LPS 诱导的血浆 [NOx] 增加产生剂量依赖性和 > 95% 的抑制。EIT 的 ED50 值为 0.4 mg/kg。用 L-精氨酸（但不是 D-精氨酸）预处理可防止死亡率，同时不影响 II 型 NOS 依赖性 NO 的产生，表明毒性可能是由于抑制其他 NOS 亚型（内皮或神经元）之一 [1 ].选择性 NOS II 拮抗剂减弱但不阻断胎儿肺中剪切应力诱导的血管舒张。NOS II 活性的刺激（可能来自平滑肌细胞）在剪切应力诱导的肺血管舒张过程中部分促成了 NO 介导的 PVR（肺血管阻力）下降。在存在 AMT 或另一种选择性 iNOS 抑制剂 S-乙基异硫脲 (EIT) 的情况下用同种异体抗原刺激的脾细胞比在没有 iNOS 抑制剂的情况下刺激的细胞产生更多的白细胞介素 (IL)-4 和 IL-10。Th1 细胞因子 IL-2 和干扰素 (IFN)-γ 的产生并未因抑制 NO 合成而增强。急性给予 EIT (380 nmol/h)，另一种诱导型一氧化氮合酶选择性抑制剂，也减弱了妊娠引起的肾小球滤过率和有效肾血浆流量的增加。

Density	1.19 g/cm3
Boiling Point	159.6ºC at 760 mmHg
Melting Point	79-81°C
Molecular Formula	C₃H₉BrN₂S
Molecular Weight	185.09
Flash Point	50.3ºC
Exact Mass	183.966980
PSA	75.17000
LogP	2.39110
Vapour Pressure	2.26mmHg at 25°C
Index of Refraction	1.548
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM6825000

CHEMICAL NAME :: Pseudourea, 2-ethyl-2-thio-, hydrobromide

CAS REGISTRY NUMBER :: 1071-37-0

LAST UPDATED :: 198706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C3-H8-N2-S.Br-H

MOLECULAR WEIGHT :: 185.11

WISWESSER LINE NOTATION :: SHYZUN2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R22
Safety Phrases	S22-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UM6825000
HS Code	2930909090

74-96-4

17356-08-0

~99%

1071-37-0

Literature: PROGENICS PHARMACEUTICALS, INC.; HAN, Amy, Qi; WANG, Eric; GAUSS, Carla; XIE, Walter; COBURN, Glen; DEMUYS, Jean-Marc Patent: WO2010/118367 A2, 2010 ; Location in patent: Page/Page column 78 ;

Precursor 1
74-96-4
DownStream 10
352-97-6 463-00-3 811-51-8 594-44-5
627-04-3 102-06-7 3088-46-8 55-67-4
112-65-2 16136-32-6

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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