672-87-7

672-87-7 structure

Name: Metyrosine
Chemical Name: α-methyl-L-tyrosine
CAS Number: 672-87-7
Molecular Formula: C₁₀H₁₃NO₃
Molecular Weight: 195.21500
Catalog: Biochemical Common amino acids and protein drugs
Create Date: 2018-09-05 01:04:06
Modify Date: 2024-01-06 22:37:21
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

Name	α-methyl-L-tyrosine
Synonyms	MFCD00064201 (S)-alpha-Methyltyrosine α-METHYL-L-P-TYROSINE alpha-methyl-L-tyrosine EINECS 211-599-5

Description	Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].
In Vivo	Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1]. Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2] Dosage: 50, 100 or 200 mg/kg Administration: I.p. Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
References	[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922509090

Precursor 3
121703-96-6 2746-25-0 122-84-9
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%