925676-48-8

925676-48-8 structure

Name: LAS101057
Chemical Name: Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]
CAS Number: 925676-48-8
Molecular Formula: C₁₈H₁₄FN₅O
Molecular Weight: 335.33500
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-03-14 08:24:46
Modify Date: 2025-08-26 10:45:47
LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.

Name	Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]
Synonyms	las-101057 LAS101057

Description	LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Inflammation/Immunology
In Vivo	At 3 mg/kg, LAS101057 is active in preventing methacholine-induced AHR, and at 10 mg/kg it inhibits AHR to methacholine to a level virtually equal to that seen with dexamethasone at 1 mg/kg[1].
References	[1]. Paul Eastwood, et al. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2011 Mar 10; 2(3): 213-218.