350228-37-4

350228-37-4 structure

Name: (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
Chemical Name: h-lys-thr-glu-glu-ile-ser-glu-val-asn-sta-val-ala-glu-phe-oh
CAS Number: 350228-37-4
Molecular Formula: C₇₃H₁₁₈N₁₆O₂₇
Molecular Weight: 1651.809
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2016-10-20 15:48:40
Modify Date: 2025-09-18 16:51:50
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase)[1].

Name	h-lys-thr-glu-glu-ile-ser-glu-val-asn-sta-val-ala-glu-phe-oh
Synonyms	L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-meth ylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]- L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-methylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]- (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-butan-2-yl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name) kteeisevn-sta-vaef b-secretase inhibitor (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-2-butanyl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name) KTEEISEVN-Sta-VAEF(Sta=statine) (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675)

Description	β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
References	[1]. Lin Liu, et al. A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide. Sensors and Actuators B: Chemical. Volume 266, 1 August 2018, Pages 246-254. [2]. Zhou Y, et al. Tyrosine-Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal-Organic Framework Composites as Electrochemical Tags. Chemistry. 2023 May 16;29(28):e202300450.

Density	1.3±0.1 g/cm3
Boiling Point	1976.1±65.0 °C at 760 mmHg
Molecular Formula	C₇₃H₁₁₈N₁₆O₂₇
Molecular Weight	1651.809
Flash Point	1148.9±34.3 °C
Exact Mass	1650.835205
PSA	720.62000
LogP	-2.42
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.562

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