Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: sodium 4,6-dichloro-3-[(E)-(2-oxo-1-phenyl-pyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

166974-23-8

166974-23-8 structure

166974-23-8 structure

Name: GV-196771A
Chemical Name: sodium,4,6-dichloro-3-[(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate
CAS Number: 166974-23-8
Molecular Formula: C₂₀H₁₃Cl₂N₂NaO₃
Molecular Weight: 423.22500
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-10-02 01:47:39
Modify Date: 2024-01-28 13:08:40
GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.

Name	sodium,4,6-dichloro-3-[(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate
Synonyms	GV-196771A

Description	GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	NMDA receptor[1]
In Vivo	GV196771 is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor. GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain. GV196771 is an NMDA receptor antagonist with low oral bioavailability in rats and mice. GV196771 has low oral bioavailability (<10%) and plasma clearance (~2 mL/min/kg) in rats[1].
Animal Admin	Mice[1] Male wild-type FVB mdr1a/1b+/+ and Pgp-deficient knockout FVBmdr1a/1b-/- mice (20-30 g) are used. Dose solutions of 0.2 mg/mL for GV196771 and 5.0 mg/mL for GF120918 are prepared fresh using 0.5% hydroxypropylmethylcellulose and 1% Tween 80 as a vehicle. Two hours before the administration of GV196771, the animals are divided into two groups. One group receive a single oral dose (10 mL/kg) of vehicle and the second group receive a single 50 mg/kg oral dose (10 mL/kg) of GF120918. Two hours later, all animals receive a single 2 mg/kg oral dose (10 mL/kg) of GV196771. At scheduled time points, mice are anesthetized with CO2 and blood samples are obtained by cardiac puncture. Blood is centrifuged to yield plasma. The MDR genotype of each animal is confirmed by a polymerase chain reaction assay after study completion.
References	[1]. Polli JW, et al. The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters. Drug Metab Dispos. 2004 Jul;32(7):722-6.

Boiling Point	644.9ºC at 760mmHg
Molecular Formula	C₂₀H₁₃Cl₂N₂NaO₃
Molecular Weight	423.22500
Flash Point	343.8ºC
Exact Mass	422.02000
PSA	76.23000
LogP	3.72350
Vapour Pressure	1.64E-17mmHg at 25°C
Storage condition	2-8℃