61890-25-3
61890-25-3 structure
- Name: (Rac)-Lanicemine
- Chemical Name: 1-Phenyl-2-(2-pyridinyl)ethanamine
- CAS Number: 61890-25-3
- Molecular Formula: C13H14N2
- Molecular Weight: 198.26400
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2019-05-27 21:44:44
- Modify Date: 2024-01-13 16:17:56
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(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
| Name | 1-Phenyl-2-(2-pyridinyl)ethanamine |
|---|---|
| Synonyms |
1-phenyl-2-pyridin-2-yl-ethylamine
2-aziridin-1-yl-1-phenyl-ethanol |
| Description | (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1]. |
|---|---|
| Related Catalog | |
| Target |
NMDA receptor[1] |
| In Vivo | Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |
| References |
| Molecular Formula | C13H14N2 |
|---|---|
| Molecular Weight | 198.26400 |
| Exact Mass | 198.11600 |
| PSA | 38.91000 |
| LogP | 3.02440 |
| HS Code | 2933399090 |
|---|
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61890-25-3 |
| Literature: Bower; Ramage Journal of the Chemical Society, 1957 , p. 4506,4509 |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |