268214-52-4

268214-52-4 structure

Name: Coronalolic acid
Chemical Name: 3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a- dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyc lopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid
CAS Number: 268214-52-4
Molecular Formula: C₃₀H₄₆O₄
Molecular Weight: 470.684
Catalog: Natural product Moss
Create Date: 2016-08-20 01:33:54
Modify Date: 2025-08-31 19:03:24
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1].

Name	3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a- dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyc lopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid
Synonyms	Coronalolic acid 1H-Cyclopenta[a]cyclopropa[e]naphthalene-6a(7H)-propanoic acid, 1-[(1R,4E)-1,5-dimethyl-6-oxo-4-hexen-1-yl]decahydro-6-[1-(hydroxymethyl)ethenyl]-3a,9a-dimethyl-, (1R,3aS,3bS,6R,6aR,7aS,9aR)- 3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a-dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyclopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid

Description	Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	NF-κB
In Vitro	Coronalolic acid has an inhibition effect against the TNF-α-induced NF-κB activity and NO production with IC50s of 15.4 μM and 15.0 μM in LPS-stimulated RAW 264.7 cells, respectively[1].
References	[1]. Youn UJ, et al. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct;114:92-97.

Hazard Codes	Xi