861891-50-1

861891-50-1 structure

Name: IM-54
Chemical Name: 1-methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione
CAS Number: 861891-50-1
Molecular Formula: C₁₉H₂₃N₃O₂
Molecular Weight: 325.405
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-06-21 16:00:46
Modify Date: 2025-08-23 08:16:32
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2].

Name	1-methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione
Synonyms	IM-54 Necrosis Inhibitor,IM-54 1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)- IN1208

Description	IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis[1]. IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM against HL-60 cells treated with H2O2[1].
References	[1]. Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9(3): 182–187. [2]. Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10(5):308-14.