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863329-66-2

863329-66-2 structure
863329-66-2 structure
  • Name: PSI-6206
  • Chemical Name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
  • CAS Number: 863329-66-2
  • Molecular Formula: C10H13FN2O5
  • Molecular Weight: 260.219
  • Catalog: Pharmaceutical intermediate API intermediate
  • Create Date: 2018-12-25 21:07:29
  • Modify Date: 2025-08-25 15:43:04
  • PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Name (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
Synonyms 2'-Deoxy-2'-fluoro-2'-methyluridine
PSI-6206
Uridine, 2'-deoxy-2'-fluoro-2'-methyl-
URI002
Ro-2433
2'-deoxy-2'-fluoro-2'-C-methyl-uridine
PSI6206
Description PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Related Catalog
Target

EC90：>100 μM (HCV replicon)[1]

In Vitro PSI-6206 (RO2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay[1]. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B[2]. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase[3].
References

[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8.

[2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29

[3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.
Density 1.6±0.1 g/cm3
Melting Point 237-238℃
Molecular Formula C10H13FN2O5
Molecular Weight 260.219
Exact Mass 260.080841
PSA 104.55000
LogP -0.77
Index of Refraction 1.596
Hazard Codes Xi
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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title: CAS No. 863329-66-2 | Chemsrc address: https://www.chemsrc.com/en/baike/523130.html

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