39967-60-7

39967-60-7 structure

Name: Deoxypseudouridine
Chemical Name: 5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
CAS Number: 39967-60-7
Molecular Formula: C₉H₁₂N₂O₅
Molecular Weight: 228.20200
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-03-14 23:33:05
Modify Date: 2024-01-09 13:50:15
Deoxypseudouridine is a nucleotide analog.

Name	5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
Synonyms	2'-DEOXYGUANOSINE-5'-TRIPHOSPHORIC ACID DISODIUM SALT 2'-Deoxypseudouridine Deoxypseudouridine

Description	Deoxypseudouridine is a nucleotide analog.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
In Vitro	Deoxypseudouridine is a nucleotide analog. Ethidium bromide staining of the gel demonstrates that the digestion of carrier DNA in both control and analog DNA samples (including Deoxypseudouridine) occur to the same extent; this indicates that the restriction enzyme is as active in the presence of the modified DNA substrate (including Deoxypseudouridine) as it is in the presence of unmodified (control) DNA. Enzymes that do not contain an AT base pair in their recognition sequence, restrict DNAs substituted with either deoxypseudouridine or deoxytubercidin as efficiently as control[1].
References	[1]. Bodnar JW, et al. Effect of nucleotide analogs on the cleavage of DNA by the restriction enzymes AluI, DdeI, HinfI, RsaI, and TaqI. J Biol Chem. 1983 Dec 25;258(24):15206-13.