144494-65-5

144494-65-5 structure

Name: Tirofiban
Chemical Name: tirofiban
CAS Number: 144494-65-5
Molecular Formula: C₂₂H₃₆N₂O₅S
Molecular Weight: 440.597
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-08-03 11:35:20
Modify Date: 2024-01-03 12:19:35
Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonistTarget: integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation. Tirofiban is an antithrombotic used in the treatment of unstable angina.Tirofiban, in a concentration-dependent manner reduced platelet aggregation evoked by ADP (IC50 approximately 70 ng/ml), collagen (IC50 approximately 200 ng/ml), and thrombin (IC50 approximately 5,000 ng/ml).

Name	tirofiban
Synonyms	Tirofiban [BAN:INN] N-(Butylsulfonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine N-(n-butanesulfonyl)-O-(4-(4-piperidinyl)butyl)-(S)-tyrosine MFCD05237246 2-S-(n-Butylsulfonylamino)-3[4-(piperidin-4-yl)butyloxyphenyl]propionic acid (S)-2-(butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)phenyl]-propionic acid Agrastat Agrastat (TN) N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]tyrosine (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid UNII-GGX234SI5H Aggrastat Tirofiban Tirofiban (INN) Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]- (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid N-(BUTYLSULFONYL)-O-[4-(4-PIPERIDINYL)BUTYL]-L-TYROSINE L-tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]- L700462 MK383

Description	Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonistTarget: integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation. Tirofiban is an antithrombotic used in the treatment of unstable angina.Tirofiban, in a concentration-dependent manner reduced platelet aggregation evoked by ADP (IC50 approximately 70 ng/ml), collagen (IC50 approximately 200 ng/ml), and thrombin (IC50 approximately 5,000 ng/ml).
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Research Areas >> Cardiovascular Disease
References	[1]. Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46. [2]. van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100. [3]. Valgimigli M, Biondi-Zoccai G, Tebaldi M et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J. 2010 Jan;31(1):35-49. [4]. Valgimigli M, Tebaldi M. Safety evaluation of tirofiban. Expert Opin Drug Saf. 2010 Sep;9(5):801-19. [5]. Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C. Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):147-53.

Density	1.2±0.1 g/cm3
Boiling Point	611.7±65.0 °C at 760 mmHg
Melting Point	223-225ºC
Molecular Formula	C₂₂H₃₆N₂O₅S
Molecular Weight	440.597
Flash Point	323.7±34.3 °C
Exact Mass	440.234497
PSA	113.11000
LogP	4.14
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.532
Storage condition	-20°C

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S22-S26-S30-S36/37/39-S45
RIDADR	UN3261
Packaging Group	II
Hazard Class	8
HS Code	2942000000

149490-61-9

~99%

144494-65-5

Literature: Chung; Zhao; Hughes; Grabowski Tetrahedron, 1993 , vol. 49, # 26 p. 5767 - 5776

108-89-4

144494-65-5

Literature: Tetrahedron, , vol. 49, # 26 p. 5767 - 5776

Precursor 2
149490-61-9 108-89-4
DownStream 0

HS Code	2942000000

144494-65-5	1332075-40-7
7440-32-6	151414-72-1
149490-61-9	57614-92-3
158808-75-4	142373-60-2
150915-40-5	149490-60-8