1036939-38-4
1036939-38-4 structure
- Name: SPV 106
- Chemical Name: Diethyl pentadecylidenemalonate
- CAS Number: 1036939-38-4
- Molecular Formula: C22H40O4
- Molecular Weight: 368.55100
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2016-12-01 03:58:44
- Modify Date: 2024-01-02 18:53:13
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SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D)[1].
| Name | Diethyl pentadecylidenemalonate |
|---|---|
| Synonyms | SPV 106 |
| Description | SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | SPV106 恢复正常水平的 H3K9Ac 和 H3K14Ac，降低 DNA CpG 高甲基化，恢复 D-CMSC 增殖和分化[1]。 SPV106 (5 µmol/L) 在 D-CMSC[1] 中减少细胞衰老并诱导 cKit 表达[1]。 Western Blot Analysis[1] Cell Line: Human cardiac-specific mesenchymal cell (CMSC) Concentration: 25 μmol/L Incubation Time: 6-8 days Result: Achieved partial but significant rescue of HAT activity. RT-PCR[1] Cell Line: Human cardiac-specific mesenchymal cell (CMSC) Concentration: 25 μmol/L Incubation Time: 7 days Result: Not associated to a rescue in gene transcription. |
| References |
| Molecular Formula | C22H40O4 |
|---|---|
| Molecular Weight | 368.55100 |
| Exact Mass | 368.29300 |
| PSA | 52.60000 |
| LogP | 6.13020 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| RIDADR | NONH for all modes of transport |
