64183-27-3

64183-27-3 structure

Name: 2′-Deoxy-2′-fluoroadenosine
Chemical Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
CAS Number: 64183-27-3
Molecular Formula: C₁₀H₁₂FN₅O₃
Molecular Weight: 269.232
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-06-29 11:13:05
Modify Date: 2024-01-04 12:30:45
2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1].

Name	(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Synonyms	2'F-dA 2'-Deoxy-2'-fluoroadenosine 2'-fluoro-2'-deoxy-adenosine Adenosine, 2'-deoxy-2'-fluoro- Adenosine,2'-deoxy-2'-fluoro

Description	2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%