64078-09-7

64078-09-7 structure

Name: CGP11952
Chemical Name: 1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-[(dimethylamino)methyl]-N-ethyl-1,2,4-triazole-3-carboxamide
CAS Number: 64078-09-7
Molecular Formula: C₂₁H₂₁Cl₂N₅O₂
Molecular Weight: 446.33000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-06-07 11:25:51
Modify Date: 2025-09-13 17:38:29
CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.

Name	1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-[(dimethylamino)methyl]-N-ethyl-1,2,4-triazole-3-carboxamide
Synonyms	CGP11952

Description	CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
Target	Benzodiazepine[2]
In Vitro	CGP11952 (CGP 11952) is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action[1]. The effects of CGP11952 (CGP 11.952), a triazolyl Benzophenone, on cognitive functioning are assessed by means of a computerized neuropsychological battery. In the first study CGP11952 turns out to have a positive effect on information processing speed, perceptual sensitivity and preciseness of responses. Negative effects are found on reaction time. In the second study this latter effect is less clear. A striking result is the less negative effect on memory consolidation under influence of CGP11952 in comparison with other benzodiazepines[2].
References	[1]. Van Wieringen A, et al. Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies. Epilepsy Res. 1987 Jan;1(1):3-15. [2]. Alpherts WC, et al. CGP 11.952: an experimental benzodiazepine derivative. Effects on cognitive functioning in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):673-82.