79644-90-9

79644-90-9 structure

Name: Vebufloxacin
Chemical Name: Vebufloxacin
CAS Number: 79644-90-9
Molecular Formula: C₁₉H₂₂FN₃O₃
Molecular Weight: 359.39500
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-06-08 16:57:50
Modify Date: 2024-01-08 18:07:56
DM8966 exhibits potent antibacterial activity against gram-positive and -negative bacteria.

Name	Vebufloxacin
Synonyms	Benofloxacin 8-(4-methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid UNII-SXI3MP1G46 1h,5h-benzo[ij]quinolizine-2-carboxylic acid,9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo 9-Fluoro-5-methyl-8-(4-methyl-1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo<ij>quinolizine-2-carboxylic acid DM8966

Description	DM8966 exhibits potent antibacterial activity against gram-positive and -negative bacteria.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
Target	Bacteria[1]
In Vitro	A series of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids is synthesized and tested for antibacterial activities. Among them, DM8966 (OPC-7241) exhibits potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, and OPC-7251 shows potent activity characteristically against Propionibacterium acnes[1].
References	[1]. Ishikawa H, et al. Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids. Chem Pharm Bull (Tokyo). 1989 Aug;37(8):2103-8.