119193-37-2

119193-37-2 structure

Name: LY278584
Chemical Name: 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)indazole-3-carboxamide
CAS Number: 119193-37-2
Molecular Formula: C₁₇H₂₂N₄O
Molecular Weight: 298.38
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-11-01 06:16:07
Modify Date: 2024-04-05 17:59:04
LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a Ki of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors[1].

Name	1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)indazole-3-carboxamide
Synonyms	1-methyl-n-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1h-indazole-3-carboxamide LY278584

Description	LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a Ki of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT3 Receptor:1.62 nM (Ki)
References	[1]. D W Robertson, et al. Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors. J Med Chem. 1990 Dec;33(12):3176-81.