DC Chemicals Limited
China
Product Name: ent-Tadalafil
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

629652-72-8

629652-72-8 structure

Name: ent-Tadalafil
Chemical Name: (6S,12aS)-tadalafil
CAS Number: 629652-72-8
Molecular Formula: C₂₂H₁₉N₃O₄
Molecular Weight: 389.40400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-06-19 15:59:05
Modify Date: 2024-01-09 10:05:29
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1].

Name	(6S,12aS)-tadalafil
Synonyms	L-Tildenafil L-Tadalafil ent-Tadalafil UNII-HZ6QJN0D4Z Tadalafil Impurity 12

Description	ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	PDE5:10 μM (IC50)
References	[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.

Density	1.51±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point	302-304 ºC
Molecular Formula	C₂₂H₁₉N₃O₄
Molecular Weight	389.40400
Exact Mass	389.13800
PSA	74.87000
LogP	2.08710
Water Solubility	Insuluble (8.6E-3 g/L) (25 ºC)

74-89-5

629652-42-2

~72%

629652-72-8

Literature: Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542