Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors

W Jiang, VC Alford, Y Qiu, S Bhattacharjee…

Index: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

Full Text: HTML

Citation Number: 25

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry. Volume 12, Issue 6, 15 March 2004, Pages 1505–1515. ... Pharmaceutical Research & Development, LLC, 1000 Route 202 South; PO Box 300, Raritan, NJ 08869, USA. ...

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H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~%

Cialis Structure

171596-29-5

Cialis

piperonal Structure

120-57-0

piperonal

~%

Cialis Structure

171596-29-5

Cialis

(1R,2S,3R)-(+)-3-[N-(BENZENESULFONYL)-N-(3,5-DIMETHYL-PHENYL)AMINO]-2-BORNANOL Structure

171596-41-1

(1R,2S,3R)-(+)-...

~%

Cialis Structure

171596-29-5

Cialis

methylamine Structure

74-89-5

methylamine

Chloropretadalafil Structure

171489-59-1

Chloropretadalafil

~54%

12-epi-TadalafilTadalafil Structure

171596-27-3

12-epi-Tadalafi...

Cialis Structure

171596-29-5

Cialis

piperonal Structure

120-57-0

piperonal

H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~23%

(1R,2S,3R)-(+)-3-[N-(BENZENESULFONYL)-N-(3,5-DIMETHYL-PHENYL)AMINO]-2-BORNANOL Structure

171596-41-1

(1R,2S,3R)-(+)-...

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate Structure

171596-42-2

methyl (1S,3R)-...

methylamine Structure

74-89-5

methylamine

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-3-(2-chloroacetyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate Structure

629652-40-0

methyl (1S,3R)-...

~18%

ent-Tadalafil Structure

629652-72-8

ent-Tadalafil

6-epi-Tadalafil Structure

171596-28-4

6-epi-Tadalafil

H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~%

ent-Tadalafil Structure

629652-72-8

ent-Tadalafil

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate Structure

171596-42-2

methyl (1S,3R)-...

~%

ent-Tadalafil Structure

629652-72-8

ent-Tadalafil

methylamine Structure

74-89-5

methylamine

Chloropretadalafil Structure

171489-59-1

Chloropretadalafil

~1%

12-epi-TadalafilTadalafil Structure

171596-27-3

12-epi-Tadalafi...

Cialis Structure

171596-29-5

Cialis

H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~%

12-epi-TadalafilTadalafil Structure

171596-27-3

12-epi-Tadalafi...

(1R,2S,3R)-(+)-3-[N-(BENZENESULFONYL)-N-(3,5-DIMETHYL-PHENYL)AMINO]-2-BORNANOL Structure

171596-41-1

(1R,2S,3R)-(+)-...

~%

12-epi-TadalafilTadalafil Structure

171596-27-3

12-epi-Tadalafi...

H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~%

6-epi-Tadalafil Structure

171596-28-4

6-epi-Tadalafil

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate Structure

171596-42-2

methyl (1S,3R)-...

~%

6-epi-Tadalafil Structure

171596-28-4

6-epi-Tadalafil

piperonal Structure

120-57-0

piperonal

~%

6-epi-Tadalafil Structure

171596-28-4

6-epi-Tadalafil

methylamine Structure

74-89-5

methylamine

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-3-(2-chloroacetyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate Structure

629652-40-0

methyl (1S,3R)-...

~21%

ent-Tadalafil Structure

629652-72-8

ent-Tadalafil

6-epi-Tadalafil Structure

171596-28-4

6-epi-Tadalafil

piperonal Structure

120-57-0

piperonal

H-D-Trp-OMe.HCl Structure

14907-27-8

H-D-Trp-OMe.HCl

~25%

(1R,2S,3R)-(+)-3-[N-(BENZENESULFONYL)-N-(3,5-DIMETHYL-PHENYL)AMINO]-2-BORNANOL Structure

171596-41-1

(1R,2S,3R)-(+)-...

methyl (1S,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate Structure

171596-42-2

methyl (1S,3R)-...


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