Name | fluticasone |
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Synonyms |
Fluticasone propionate (JAN/USAN)
Flonase Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(fluoromethyl) ester, (6α,11β,16α,17α)- S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate Flovent DPI UNII-CUT2W21N7U Flixonase Flutionum Flutiona [Spanish] (6α,11β,16α,17α)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate Flixotide Fluticasone Fluticasone propionate Flutiona flutione Fluticaps (TN) (6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid S-(Fluoromethyl) Ester flovent diskus Flutionum [Latin] Flutione (INN) Cutivate MFCD01862254 |
Description | Fluticasone is an inhaled corticosteroid used for respiratory diseases[1]. Fluticasone is a Smo agonist s with a IC50 value of 99 nM. Fluticasone activate Hedgehog signaling and promotes the proliferation of primary neuronal stem/precursor cells[2]. |
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Related Catalog | |
In Vitro | Fluticasone (0-10 μM, 2 hours) inhibits the U2OS cells growth with the EC50 of 99 nM[2]. Fluticasone (10-1000 nM, 48 hours) decreases HRV-induced mucin production and involves modulation of SPDEF-regulated genes and extracellular ATP release[3]. |
In Vivo | Fluticasone (intranasal dropping; 1mg/kg; 7 days) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4]. Animal Model: C57BL/6 mice[4] Dosage: 1 mg/kg Administration: Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days Result: Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 568.3±50.0 °C at 760 mmHg |
Melting Point | -18.1ºC |
Molecular Formula | C25H31F3O5S |
Molecular Weight | 500.571 |
Flash Point | 297.5±30.1 °C |
Exact Mass | 500.184418 |
PSA | 105.97000 |
LogP | 3.73 |
Vapour Pressure | 0.0±3.5 mmHg at 25°C |
Index of Refraction | 1.556 |