DC Chemicals Limited
China
Product Name: (S)-(-)-HA 966
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Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLICACID1-BENZYLESTER
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Purity: 98.0%
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111821-58-0

111821-58-0 structure

Name: (S)-(-)-HA-966
Chemical Name: (s)-(-)-3-amino-1-hydroxypyrrolidin-2-one
CAS Number: 111821-58-0
Molecular Formula: C₄H₈N₂O₂
Molecular Weight: 116.11900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-12-27 20:52:43
Modify Date: 2024-01-04 18:51:44
(S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].

Name	(s)-(-)-3-amino-1-hydroxypyrrolidin-2-one
Synonyms	l-a-amino-e-n-benzyl-caprolactam 7-Nitroindazole

Description	(S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	On cultured cortical neurones (+)-HA-966 inhibits glycine-potentiated NMDA responses with an IC50=13 μM compared with (-)-HA-966 (IC50=708 μM)[2].
In Vivo	(S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1]. (S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1]. (S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1].
References	[1]. B A Morrow, et al. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. J Pharmacol Exp Ther. 1997 Nov;283(2):712-21. [2]. L Singh, et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51.

Density	1.436 g/cm3
Boiling Point	258.6ºC at 760 mmHg
Molecular Formula	C₄H₈N₂O₂
Molecular Weight	116.11900
Flash Point	110.2ºC
Exact Mass	116.05900
PSA	66.56000

127977-32-6

111821-58-0

Literature: Williams; Leeson; Hannah; Baker Journal of the Chemical Society - Series Chemical Communications, 1989 , # 22 p. 1740 - 1742

111772-93-1

~98%

111821-58-0

Literature: Fushiya; Maeda; Funayama; Nozoe Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 480 - 483

Precursor 1
111772-93-1
DownStream 0

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