Name | 20-hete |
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Synonyms |
20-hydroxy-5,8,11,14-eicosatetraenoic acid
20-HETE 20-Hydroxyicosatetraenoic acid 5,8,11,14-Eicosatetraenoic acid, 20-hydroxy-, (5Z,8Z,11Z,14Z)- DSR-II-247-30 (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid 20-Hydroxyeicosatetraenoic acid 20-Hydroxyicosatetraenoate 20-Hydroxy arachidonic acid (5Z,8Z,11Z,14Z)-20-Hydroxy-5,8,11,14-icosatetraenoic acid |
Description | 20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels.IC50 Value:Target: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension. in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2].in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice had overexpressed hepatic CYP4F2, high hepatic 20-HETE and fasting plasma glucose levels but normal insulin level. The GP activity was increased and the cAMP/PKA-PhK-GP pathway was activated in the transgenic mice compared with wild-type mice [5]. Clinical trial: Mechanisms of Response to Diesel Exhaust in Subjects With Asthma. Phase not specified |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 482.0±33.0 °C at 760 mmHg |
Molecular Formula | C20H32O3 |
Molecular Weight | 320.47 |
Flash Point | 259.4±21.9 °C |
Exact Mass | 320.235138 |
PSA | 57.53000 |
LogP | 4.91 |
Vapour Pressure | 0.0±2.7 mmHg at 25°C |
Index of Refraction | 1.515 |
Storage condition | −20°C |
Symbol |
GHS02, GHS07 |
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Signal Word | Danger |
Hazard Statements | H225-H319 |
Precautionary Statements | P210-P305 + P351 + P338-P370 + P378-P403 + P235 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | F: Flammable;Xi: Irritant; |
Risk Phrases | 11-36/37/38 |
Safety Phrases | 16-26-36 |
RIDADR | UN 1170 3/PG 2 |
WGK Germany | 3 |
Precursor 7 | |
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DownStream 0 |