344768-30-5

344768-30-5 structure

Name: UBP141
Chemical Name: 1-(3-Phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid
CAS Number: 344768-30-5
Molecular Formula: C₂₁H₁₈N₂O₅
Molecular Weight: 378.38
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-01-31 21:08:29
Modify Date: 2024-01-11 11:04:53
UBP141 is a GluN2C/2D (NR2C/2D)-preferring receptor antagonist, with Kds of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice[1][2].

Name	1-(3-Phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid
Synonyms	UBP141

Description	UBP141 is a GluN2C/2D (NR2C/2D)-preferring receptor antagonist, with Kds of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Morley RM, et, al. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. [2]. Yamamoto H, et, al. Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity. Mol Brain. 2013 Dec 16;6:56.