77-39-4

77-39-4 structure

Name: cycrimine
Chemical Name: cycrimine
CAS Number: 77-39-4
Molecular Formula: C₁₉H₂₉NO
Molecular Weight: 287.44000
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-09-06 19:04:32
Modify Date: 2024-01-18 19:50:43
Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].

Name	cycrimine
Synonyms	Cycriminum [INN-Latin] Cicrimina 1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol Cicrimina [INN-Spanish] Cycriminum 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol 1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol Pagitane 1-Cyclopentyl-1-phenyl-1-piperidino-propan-1-ol

Description	Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1. [2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344. [3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165. [4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

73-63-2

33240-34-5

77-39-4

Literature: Denton et al. Journal of the American Chemical Society, 1950 , vol. 72, p. 3792

Precursor 2
73-63-2 33240-34-5
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