Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Vinconate
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70704-03-9

70704-03-9 structure

70704-03-9 structure

Name: Vinconate
Chemical Name: Vinconate
CAS Number: 70704-03-9
Molecular Formula: C₁₈H₂₀N₂O₂
Molecular Weight: 296.36400
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-03-23 08:00:00
Modify Date: 2024-01-01 23:35:23
Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

Name	Vinconate
Synonyms	UNII-807MP0MJ61 Vinconato Vinconatum [INN-Latin] VINCANTENATE Vinconatum Vinconato [INN-Spanish] Vincantemat

Description	Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease
Target	muscariic acetylcholine receptor[1]
In Vivo	Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2].
Animal Admin	344 male rats, 6 months (adult) and 24 months (aged) of age, are allowed food and water ad lib throughout the experiments. Rats are divided into four groups; (1) 6-month-old; (2) vehicle (distilled water) is administered intraperitoneally (i.p.) once a day for 4 weeks before decapitation; (3) Vinconate at a dose of 10 mg/kg is administered i.p. once a day for 4 weeks before decapitation; (4) Vinconate at a dose of 30 mg/kg is administered i.p. once a day for 4 weeks before decapitation. Rats in groups (2) to (4) are 24 months old. Each group contains 6 to 7 rats. In addition, there are no significant differences among the three aged animal groups in body weight after drug or vehicle treatment[2].
References	[1]. Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. [2]. Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9.

Density	1.27g/cm3
Boiling Point	363.6ºC at 760 mmHg
Molecular Formula	C₁₈H₂₀N₂O₂
Molecular Weight	296.36400
Flash Point	173.7ºC
Exact Mass	296.15200
PSA	34.47000
LogP	2.91590
Index of Refraction	1.654
Storage condition	2-8℃

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