Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: dicycloverine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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77-19-0

77-19-0 structure

Name: dicycloverine
Chemical Name: dicyclomine
CAS Number: 77-19-0
Molecular Formula: C₁₉H₃₅NO₂
Molecular Weight: 309.48700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-11-14 11:12:13
Modify Date: 2024-01-07 06:14:45
Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].

Name	dicyclomine
Synonyms	Dicyclohexylhydroxyphenylstannane [1,1'-bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester Stannane,dicyclohexylhydroxyphenyl dicycloverine Dicyclohexylphenyltin hydroxide Bicyclohexyl-1-carbonsaeure-(2-diaethylamino-aethylester) bicyclohexyl-1-carboxylic acid-(2-diethylamino-ethyl ester) Dicyclomine

Description	Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR
In Vivo	Dicyclomine (Dicycloverine) (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice[2]. Dicyclomine (Dicycloverine) (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks[3]. Animal Model: C57Bl/6 mice[1] Dosage: 2.0, 4.0, and 8.0 mg/kg Administration: Intraperitoneal injection; daily; 7 days Result: Produced impairments due to actions of the agent outside of the hippocampus.
References	[1]. Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. [2]. Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. [3]. Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48.

Molecular Formula	C₁₉H₃₅NO₂
Molecular Weight	309.48700
Exact Mass	309.26700
PSA	29.54000
LogP	4.40220

64-17-5

77-19-0

Literature: Tilford; Van Campen; Shelton Journal of the American Chemical Society, 1947 , vol. 69, p. 2902,2904

60263-54-9

77-19-0

Literature: Yoshida; Iwashige Pharmaceutical Bulletin, 1955 , vol. 3, p. 417,420

30381-48-7

83803-75-2

77-19-0

Literature: Verrier Bulletin de la Societe Chimique de France, 1959 , p. 1863

100-35-6

77-19-0

Literature: Kopp; Tchoubar Bulletin de la Societe Chimique de France, 1952 , p. 84

92110-93-5

100-37-8

77-19-0

Literature: Kopp; Tchoubar Bulletin de la Societe Chimique de France, 1952 , p. 84

Precursor 6
64-17-5 60263-54-9 30381-48-7 83803-75-2
100-35-6 100-37-8
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4