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808-48-0

808-48-0 structure
808-48-0 structure
  • Name: Desoxycorticosterone pivalate
  • Chemical Name: 11-deoxycorticosterone pivalate
  • CAS Number: 808-48-0
  • Molecular Formula: C26H38O4
  • Molecular Weight: 414.57800
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-07-31 14:36:05
  • Modify Date: 2024-01-02 10:07:39
  • Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism[1][2].
Name 11-deoxycorticosterone pivalate
Synonyms 21-pivaloyloxy-pregn-4-ene-3,20-dione
Desoxycorticosterone pivalate
neodin-depositum
MFCD00199992
21-Pivaloyloxy-pregn-4-en-3,20-dion
Percorten pivalate
deoxycorticosterone pivalate
percortenm
Desoxycortisone pivalate
DOC PIVALATE
docp
cortexonem
deoxycortonepivalate
desoxycortone pivalate
EINECS 212-366-0
Description Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism[1][2].
Related Catalog
In Vivo A starting dosage of 1.5 mg/kg Desoxycorticosterone pivalate (DOCP) is effective in controlling clinical signs and serum electrolyte concentrations in the majority of dogs with PH. An additional dose reduction often is needed to maintain an injection interval of 28-30 days. Young and growing animals seem to need higher dosages[1].
References

[1]. Sieber-Ruckstuhl NS, et al. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. J Vet Intern Med. 2019 May;33(3):1266-1271.

[2]. Masticatory Muscle Myositis: Pathogenesis, Diagnosis, and Treatment.
Density 1.111 g/cm3
Boiling Point 529.012ºC at 760 mmHg
Melting Point 198-204ºC
Molecular Formula C26H38O4
Molecular Weight 414.57800
Exact Mass 414.27700
PSA 60.44000
LogP 5.29290
Index of Refraction 1.534
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5021400
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-
CAS REGISTRY NUMBER :
808-48-0
BEILSTEIN REFERENCE NO. :
3174879
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C26-H38-O4
MOLECULAR WEIGHT :
414.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
119 mg/kg/24W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in thyroid weight Related to Chronic Data - changes in testicular weight
REFERENCE :
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940- Volume(issue)/page/year: 54,1954,1993
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332
Precautionary Statements P261-P280-P301 + P312 + P330
RIDADR NONH for all modes of transport
68-96-2 structure

68-96-2
3282-30-2 structure

3282-30-2

~%

808-48-0 structure

808-48-0
Literature: Helvetica Chimica Acta, , vol. 34, p. 354,358
Precursor  2

DownStream  0


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