181630-15-9

181630-15-9 structure

Name: Picoplatin
Chemical Name: azane,2-methylpyridine,platinum(2+),dichloride
CAS Number: 181630-15-9
Molecular Formula: C₆H₇Cl₂NPt
Molecular Weight: 376.147
Catalog: Research Areas Cancer
Create Date: 2018-09-08 18:26:06
Modify Date: 2025-08-22 09:23:13
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA[1].

Name	azane,2-methylpyridine,platinum(2+),dichloride
Synonyms	Platinum(2+) chloride - 2-methylpyridine ammoniate (1:2:1:1) Picoplatin cis-amminedichloro(2-methylpyridine)platinum(II) cis-amminedichlorido(2-methylpyridine)platinum(II) cis-amminedichloro(2-picoline)platinum(II) Pyridine, 2-methyl-, platinum(2+) salt, hydrochloride, ammoniate (1:1:2:1) ZD 0473 Picoplatin [INN:BAN] (SP-4-3)-Amminedichloro(2-methylpyridine)platinium AMD 473 cis-PtCl2(NH3)(2-picoline)

Description	Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. J Holford, et al. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br J Cancer. 1998;77(3):366-73.