1119-62-6

1119-62-6 structure

Name: 3,3'-Disulfanediyldipropanoic acid
Chemical Name: 3,3′-Dithiodipropionic acid
CAS Number: 1119-62-6
Molecular Formula: C₆H₁₀O₄S₂
Molecular Weight: 210.271
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-05-05 08:00:00
Modify Date: 2025-08-20 17:58:03
Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].

Name	3,3′-Dithiodipropionic acid
Synonyms	MFCD00002780 3-(2-carboxyethyldisulfanyl)propanoic acid Propanoic acid, 3,3'-dithiobis- 3,3'-Dithiodipropionic acid 3,3'-Disulfanediyldipropanoic acid EINECS 214-284-0 3,3-Dithiodipropionic Acid 3,3‘-Dithiodipropionic acid

Description	Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1]. CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1]. CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1].
References	[1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C:Corrosive;
Risk Phrases	R34
Safety Phrases	S26-S36
RIDADR	1759
WGK Germany	3
Packaging Group	III
Hazard Class	8
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%