853910-02-8
853910-02-8 structure
- Name: NVP-BAG956
- Chemical Name: 2-methyl-2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile
- CAS Number: 853910-02-8
- Molecular Formula: C28H21N5
- Molecular Weight: 427.500
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2016-02-26 02:50:24
- Modify Date: 2024-01-02 14:52:51
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NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
| Name | 2-methyl-2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile |
|---|---|
| Synonyms |
cc-502
BAG956 2-Methyl-2-(4-(2-methyl-8-((pyridin-3-yl)ethynyl)imidazo(4,5-C)quinolin-1-yl)phenyl)propionitrile Benzeneacetonitrile, α,α-dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]- 2-Methyl-2-{4-[2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile 2-Methyl-2-{4-[2-methyl-8-(3-pyridinylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile NVP-BAG956 UNII-4UFC2K6E50 |
| Description | NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. |
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| Related Catalog | |
| Target |
PI3Kδ:35 nM (IC50) PI3Kα:56 nM (IC50) PI3Kγ:117 nM (IC50) PI3Kβ:446 nM (IC50) PDK1:240 nM (IC50) VEGFR1:2.56 μM (IC50) |
| In Vitro | NVP-BAG956 also inhibits PDK1 with an IC50 of 240/260 nM. NVP-BAG956 also inhibits VEGFR1 with an IC50 of 2.56±0.56 μM. NVP-BAG956 blocks phosphorylation of PKB/Akt in A2058 cells with an IC50 value of 67±25 nM. Inhibition of PKB/Akt phosphorylation correlated with loss of A2058 cell proliferation for NVP-BAG956 (IC50=290±20 nM). In the presence of NVP-BAG956, A2058 cells are only able to exit G2-M and then remain in G1. The p27 Kip1 expression is clearly induced by NVP-BAG956 in A2058 cells but not in C32 cells[1]. |
| Cell Assay | One day after plating (7×103 cells/cm2), melanoma cells (A2058, B16F1, B16F10, C32, HBL, Malme, Malme3M, NA8, SKMel2, SKMel23, A375, Hs294T, WM35, and 1205lu cells) are exposed to LY294002 (25 μM), Wortmannin (500 nM), NVP-BAG956 (1 μM), NVP-BBD130 (1 μM), NVP-BEZ235 (1 μM), and ZSTK474 (1 μM), and Rapamycin (100 nM). Compound concentrations are set 2 log units above the IC50 in vitro to ensure full PI3K inhibition, except for the μM inhibitor LY294002. Cells are trypsinized and counted, and the volume is quantified using a Casy Counter and Analyser. To determine the nuclear volume, cells are resuspended in CASYton containing 0.5% Triton X-100, followed by repetitive pipetting (8×), before volume measurements[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 694.8±65.0 °C at 760 mmHg |
| Molecular Formula | C28H21N5 |
| Molecular Weight | 427.500 |
| Flash Point | 374.0±34.3 °C |
| Exact Mass | 427.179688 |
| PSA | 67.39000 |
| LogP | 4.75 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.655 |
| Storage condition | -20℃ |