Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Butibufen
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Purity: 99.29%
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DC Chemicals Limited
China
Product Name: FF-106
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: FF-106
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: butibufen
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55837-18-8

55837-18-8 structure

55837-18-8 structure

Name: Butibufen
Chemical Name: 2-[4-(2-methylpropyl)phenyl]butanoic acid
CAS Number: 55837-18-8
Molecular Formula: C₁₄H₂₀O₂
Molecular Weight: 220.30700
Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
Create Date: 2018-03-29 08:00:00
Modify Date: 2025-09-11 18:32:57
Butibufen is a non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation[1][2].

Name	2-[4-(2-methylpropyl)phenyl]butanoic acid
Synonyms	Butibufenum [INN-Latin] Butilopan 2-(p-Isobutylphenyl)butyrate 2-(4-isobutylphenyl)-butyric acid 2-(4-Isobutylphenyl)butanoic acid Butibufeno [INN-Spanish] EINECS 259-849-2 2-(4-Isobutylphenyl)buttersaeure Butibufen Butibufene [INN-French]

Description	Butibufen is a non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose[2]. Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure[2]. Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes[2]. Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis[2]. Cell Viability Assay[2] Cell Line: Hepatocytes from Sprague-Dawley male rats Concentration: 0.1 μM-0.1 M Incubation Time: 60 min Result: Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.
In Vivo	Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity[3]. Animal Model: Sprague-Dawley rats[3] Dosage: 50 and 250 mg/kg Administration: Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice Result: Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
References	[1]. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. [2]. Castell JV, et al. A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica. 1988 Jun;18(6):737-45. [3]. Alamo C, et al. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol.

Density	1.015g/cm3
Boiling Point	335.1ºC at 760mmHg
Melting Point	51-53°
Molecular Formula	C₁₄H₂₀O₂
Molecular Weight	220.30700
Flash Point	232.1ºC
Exact Mass	220.14600
PSA	37.30000
LogP	3.46330
Index of Refraction	1.515
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET5030000

CHEMICAL NAME :: Butyric acid, 2-(4-isobutylphenyl)-

CAS REGISTRY NUMBER :: 55837-18-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H20-O2

MOLECULAR WEIGHT :: 220.34

WISWESSER LINE NOTATION :: QVY2&R D1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,130,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,77,1978

7664-93-9 structure

7664-93-9

61147-34-0 structure

61147-34-0

~%

55837-18-8 structure

55837-18-8

Literature: US4381313 A1, ;

Precursor 2
7664-93-9 61147-34-0
DownStream 1
61147-36-2

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