Name | 2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]-N-(2-pyridin-3-ylethyl)benzamide |
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Synonyms |
unii-q1b712v03a
ave-0118 |
Description | AVE-0118 is a nonselective Kv1.5 blocker with an IC50 of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against IKs, IKATP, and L-type Ca+ channels[1]. |
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Related Catalog | |
Target |
IC50: 1.1 μM (Kv1.5), 3.4 uM (Ito), 4.5 uM (IKAch), 8.4 uM (IKr)[1] |
In Vitro | AVE-0118 是一种 Kv1.5 阻滞剂 (IC50 = 1.1 uM),对 Ito (3.4 uM)、IKr (8.4 uM) 和 IKAch (4.5 uM) 具有中等选择性,对IKs、IK1、IKATP 具有良好的选择性[1]。 AVE-0118 (10 μM) 显著增强电场刺激 (EFS) 诱导的神经源性收缩[2]。 |
In Vivo | 在 3 mg/kg 剂量下,AVE-0118 降低了心房重构山羊 AF 的诱导性,在 5mg/kg 也并没有延长 QTc[1]。 |
References |
Molecular Formula | C30H29N3O3 |
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Molecular Weight | 479.57 |
Exact Mass | 479.22100 |
PSA | 87.30000 |
LogP | 6.00370 |