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2150-48-3

2150-48-3 structure
2150-48-3 structure
  • Name: PYRONINE B
  • Chemical Name: [6-(diethylamino)xanthen-3-ylidene]-diethylazanium,chloride
  • CAS Number: 2150-48-3
  • Molecular Formula: C21H27ClN2O
  • Molecular Weight: 358.905
  • Catalog: Biochemical Biochemical reagent Biological dye
  • Create Date: 2018-03-23 08:00:00
  • Modify Date: 2024-01-04 17:54:11
  • Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor[1][2].
Name [6-(diethylamino)xanthen-3-ylidene]-diethylazanium,chloride
Synonyms Ethanaminium, N-[6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride (1:1)
Ethanaminium, N-[6- (diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride
Pyronine B,purified
E tetraethylpyronin
[6-(Diethylamino)-3H-xanthen-3-ylidene]diethylammonium chloride
3.6-Bis-diaethylamino-xanthylium-chlorid
Pyronin B
6-(Diethylamino)-N,N-diethyl-3H-xanthen-3-iminium chloride
MFCD00011932
Ammonium, [6- (diethylamino)-3H-xanthen-3-ylidene]diethyl-, chloride
EINECS 218-429-9
3,6-bis-diethylamino xanthylium chloride
PYRONINE B
Description Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor[1][2].
Related Catalog
In Vitro Pyronin B (0-15 μM) inhibits channel activity of approximately 60% of small hydrophobic (SH) proteins at a concentration of 10 μM, and the Kd value of 6.8 μM[1]. Pyronin B (0-0.25 μM) affects RSV replication in Vero cells in a dose-dependent manner, and its TCID 50 (50% tissue culture infection dose) = 0 at the concentration of 0.25 μM[1]. Pyronin B (10 μM) can react with bromate in an oxidation reaction and the reaction rate increases dramatically with the addition of trace amounts of Ti (IV) with the characteristic absorption spectra of 555 nm[2].
References

[1]. Yan Li, et al. Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. J Virol. 2014 Oct;88(20):11899-914.

[2]. Zhou Z R, et al. Study of the Catalytic Effects of Trace Titanium on Oxidation of Pyronin B with Hydrogen Peroxide and Its Application[C]//Advanced Materials Research. Trans Tech Publications Ltd, 2013, 602: 1233-1237.
Melting Point 174-176ºC
Molecular Formula C21H27ClN2O
Molecular Weight 358.905
Exact Mass 358.181183
PSA 19.39000
LogP 1.19980
Appearance crystals | Green needles or
Storage condition Store at RT.
Water Solubility Soluble in water, ethyl acetate, methyl acetate, ethylene glycol; slightly soluble in ethanol, methanol, methyl cellosolve

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP6832000
CHEMICAL NAME :
Ammonium, (6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride
CAS REGISTRY NUMBER :
2150-48-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C21-H27-N2-O.Cl
MOLECULAR WEIGHT :
358.95
WISWESSER LINE NOTATION :
T C666 BO EYJ EUK2&2 MN2&2 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3951 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 162 (estimated) No. of Female Employees: 124 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R68
Safety Phrases S22;S45;S24/25;S36/S37
RIDADR NONH for all modes of transport
RTECS BP6832000
6274-83-5 structure

6274-83-5

~54%

2150-48-3 structure

2150-48-3
Literature: WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel Patent: WO2010/67078 A2, 2010 ; Location in patent: Page/Page column 65 ;
916308-37-7 structure

916308-37-7

~80%

2150-48-3 structure

2150-48-3
Literature: Han, Shulei; Chen, Yi Dyes and Pigments, 2013 , vol. 96, # 1 p. 59 - 62
7647-01-0 structure

7647-01-0
64-18-6 structure

64-18-6
56-81-5 structure

56-81-5
91-68-9 structure

91-68-9

~%

Detail
Literature: Journal of the Chemical Society, , p. 244,247
Precursor  5

DownStream  0


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title: CAS No. 2150-48-3 | Chemsrc address: https://www.chemsrc.com/en/baike/405648.html

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