76706-55-3
76706-55-3 structure
- Name: Myxothiazol
- Chemical Name: myxothiazol
- CAS Number: 76706-55-3
- Molecular Formula: C25H33N3O3S2
- Molecular Weight: 487.67800
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2018-09-04 11:02:10
- Modify Date: 2024-01-06 20:45:19
-
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].
| Name | myxothiazol |
|---|---|
| Synonyms |
2,6-Heptadienamide,7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-,(2E,4R,5S,6E)
MFCD00043397 MYXOTHIAZOL 7-(2 5-dimethoxy-4-methyl 2,6-Heptadienamide,7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl |
| Description | Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2]. Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3]. |
| In Vivo | Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3]. Animal Model: C57Bl/J6 mice[3] Dosage: 0.56 mg/kg Administration: I.p.; 24 hours intervals for at most 4 times Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |
| References |
| Density | 1.158g/cm3 |
|---|---|
| Boiling Point | 679.6ºC at 760 mmHg |
| Molecular Formula | C25H33N3O3S2 |
| Molecular Weight | 487.67800 |
| Flash Point | 364.8ºC |
| Exact Mass | 487.19600 |
| PSA | 143.81000 |
| LogP | 6.51870 |
| Index of Refraction | 1.584 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Hazard Codes | T+ |
| Risk Phrases | 28 |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
|
~59%
76706-55-3 |
| Literature: Iwaki, Yuki; Kaneko, Masahiro; Akita, Hiroyuki Tetrahedron Asymmetry, 2009 , vol. 20, # 3 p. 298 - 304 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |