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4429-63-4

4429-63-4 structure
4429-63-4 structure
  • Name: Tabersonine
  • Chemical Name: tabersonine
  • CAS Number: 4429-63-4
  • Molecular Formula: C21H24N2O2
  • Molecular Weight: 336.427
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-08-10 10:20:30
  • Modify Date: 2025-08-20 18:21:13
  • Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].
Name tabersonine
Synonyms EINECS 224-615-0
(-)-Tabersonine
TABERSONINE
Methyl (5α,19α)-2,3,6,7-tetradehydroaspidospermidine-3-carboxylate
methyl 2,3,6,7-tetradehydro-5α,12β,19α-aspidospermidine-3-carboxylate
Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-, methyl ester, (5α,19α)-
Description Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].
Related Catalog
References

[1]. Zhang D, et al. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. Biochem Pharmacol. 2018 Aug;154:183-192.
Density 1.3±0.1 g/cm3
Boiling Point 488.7±45.0 °C at 760 mmHg
Molecular Formula C21H24N2O2
Molecular Weight 336.427
Flash Point 249.4±28.7 °C
Exact Mass 336.183777
PSA 41.57000
LogP 3.57
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.652
Storage condition 2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CJ0150000
CHEMICAL NAME :
Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetrahydro-, methyl ester, (5-alpha,12-beta, 19-alpha)-
CAS REGISTRY NUMBER :
4429-63-4
BEILSTEIN REFERENCE NO. :
0050163
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H24-N2-O2
MOLECULAR WEIGHT :
336.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,123,1955
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport
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