68236-13-5

68236-13-5 structure
68236-13-5 structure

Name 6-prenylnaringenin
Synonyms YS03
6-Prenylnaringenin
5,7,4'-Trihydroxy-6-prenylflavanone
(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
Description (2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin acts as a GABAA positive allosteric modulator at α+β- binding interface[1].
Related Catalog
In Vitro (2S)-6-Prenylnaringenin (6-Prenylnaringenin) displays a modulatory activity at low micromolar concentrations. (2S)-6-Prenylnaringenin potentiates GABA-induced displacement of [3H]EBOB binding in a concentration-dependent manner where the IC50 value for this potentiation in native GABAA receptors is 3.7 μM, respectively[1].
References

[1]. Ali Y Benkherouf, et al. Hops Compounds Modulatory Effects and 6-prenylnaringenin Dual Mode of Action on GABA AReceptors. Eur J Pharmacol. 2020 Apr 15;873:172962.

Density 1.314±0.06 g/cm3
Molecular Formula C20H20O5
Molecular Weight 340.37000
Exact Mass 340.13100
PSA 86.99000
LogP 4.01860
Storage condition 2-8°C
Water Solubility Insuluble (9.2E-3 g/L) (25 ºC)
RIDADR NONH for all modes of transport
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