Name | 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide |
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Synonyms |
unii-8y3gdt6ywv
1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]- s7329 3-(3,5-Dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide IOWH032 IOWH-032 iowh 032 |
Description | IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1]Target: CFTRProfiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (choleratoxin), up to 8 hours after a single 5 mg/kg po dose. |
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Related Catalog | |
References |
Density | 1.7±0.1 g/cm3 |
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Molecular Formula | C22H15Br2N3O4 |
Molecular Weight | 545.180 |
Exact Mass | 542.942932 |
PSA | 97.22000 |
LogP | 7.13 |
Index of Refraction | 1.665 |
Storage condition | -20°C |
Hazard Codes | Xi |
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