2792-66-7

2792-66-7 structure

Name: 2-amino-2-methylsuccinic acid
Chemical Name: 2-amino-2-methylbutanedioic acid
CAS Number: 2792-66-7
Molecular Formula: C₅H₉NO₄
Molecular Weight: 147.12900
Catalog: Biochemical Amino acids and their derivatives Aspartic acid derivative
Create Date: 2018-12-28 13:00:59
Modify Date: 2024-01-14 07:50:02
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine[1].

Name	2-amino-2-methylbutanedioic acid
Synonyms	2-Amino-2-methylsuccinic acid D-Aspartic acid,2-methyl-,hydrochloride (1:1) 2-Methylaspartic acid MFCD00056709 Aspartic acid,2-methyl 2-Amino-2-methyl-bernsteinsaeure

Description	α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	α-methyl-dl-aspartic acid can significantly reduce the anti-hypertensive activity of Bj-BPP-10c in SHR[2].
In Vivo	α-methyl-dl-aspartic acid (147 mg/kg, i.v.) can diminish the l-citrulline-induced retinal vasodilation in Wistar rats[1]. Animal Model: Wistar rats Dosage: 147 mg/kg Administration: 147 mg/kg, i.v. Result: Attenuated the increase of retinal arteriolar diameter induced by L-citrulline.
References	[1]. Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23. [2]. Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922499990

Precursor 0
DownStream 2
498-24-8 513-88-2

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%