67953-08-6
67953-08-6 structure
- Name: GPNA hydrochloride
- Chemical Name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
- CAS Number: 67953-08-6
- Molecular Formula: C11H14ClN3O5
- Molecular Weight: 303.69900
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-03 03:40:51
- Modify Date: 2024-01-02 10:08:01
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GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
| Name | L-Glutamic acid γ-(p-nitroanilide) hydrochloride |
|---|---|
| Synonyms | L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE |
| Description | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. |
|---|---|
| Related Catalog | |
| Target |
ASCT2[1] |
| In Vitro | GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM. |
| References |
| Boiling Point | 590.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H14ClN3O5 |
| Molecular Weight | 303.69900 |
| Flash Point | 311ºC |
| Exact Mass | 303.06200 |
| PSA | 138.24000 |
| LogP | 2.82390 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |