245075-84-7
245075-84-7 structure
- Name: LR-90
- Chemical Name: 2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phe nyleneoxy]}bis(2-methylpropanoic acid)
- CAS Number: 245075-84-7
- Molecular Formula: C35H34Cl2N4O8
- Molecular Weight: 709.57200
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-07-02 01:09:30
- Modify Date: 2025-08-25 14:31:08
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LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes[1]. LR-90 is also used in the research of diabetic animal model[2].
| Name | 2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phe nyleneoxy]}bis(2-methylpropanoic acid) |
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| Description | LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes[1]. LR-90 is also used in the research of diabetic animal model[2]. |
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| Related Catalog | |
| Target |
AGE[1] |
| In Vitro | LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours[1]. LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours[1]. LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells[1]. Cell Viability Assay[1] Cell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: 24 hours Result: Showed no cytotoxicity to THP-1 cells. RT-PCR[1] Cell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: One hour before S100b addition for 4 hours Result: Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b. |
| In Vivo | LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats[2]. LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation[2]. Animal Model: Male ZDF rats (13 to 40 weeks)[2] Dosage: 50 mg/L Administration: P.O. for 27 weeks Result: Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight. |
| References |
| Molecular Formula | C35H34Cl2N4O8 |
|---|---|
| Molecular Weight | 709.57200 |
| Exact Mass | 708.17500 |
| PSA | 182.30000 |
| LogP | 8.52940 |
| Storage condition | 2-8℃ |