76150-91-9

76150-91-9 structure

Name: TCPOBOP
Chemical Name: 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine
CAS Number: 76150-91-9
Molecular Formula: C₁₆H₈Cl₄N₂O₂
Molecular Weight: 402.05900
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2016-11-11 23:34:42
Modify Date: 2025-08-27 18:52:06
TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

Name	3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine
Synonyms	2,2'-[1,4-phenylenebis(oxy)]bis(3,5-dichloropyridine) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene tcpobop 1,4-BDPOB 2,2'-[benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine)

Description	TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Others
Target	Bcl-2
In Vivo	TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1]. Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] Dosage: 3 mg/kg Administration: Oral; 1, 2, 5 days Result: Increased Liver weight to body weight.
References	[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718. [2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,1147,1988

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT7145000