Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Guanidinoethylmercaptosuccinic Acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GEMSA
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

77482-44-1

77482-44-1 structure

77482-44-1 structure

Name: 2-Guanidinoethylmercaptosuccinic Acid
Chemical Name: 2-[2-(diaminomethylideneamino)ethylsulfanyl]butanedioic acid
CAS Number: 77482-44-1
Molecular Formula: C₇H₁₃N₃O₄S
Molecular Weight: 235.26100
Catalog: Research Areas Neurological Disease
Create Date: 2016-11-14 16:30:29
Modify Date: 2025-08-25 22:32:18
GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].

Name	2-[2-(diaminomethylideneamino)ethylsulfanyl]butanedioic acid
Synonyms	(2-guanidinoethylmercapto)succinic DL-guanidinoethylmercaptosuccinic acid 2-(2-guanidinoethylthio) succinic acid 2-guanidinoethylmercaptosuccinic acid gemsa 2-[(2-carbamimidamidoethyl)sulfanyl]succinic acid Guanidinoethyl-Mercaptosuccinic Acid

Description	GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Encephalin convertase, Ki 值为8.8 nM.
In Vitro	GEMSA inhibits the activation of TAFI and porcine CBB[1]. GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin[1]. GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC50 values of 0.34 μM, 100μM, 115 μM, 90 μM respectively[1][2].
In Vivo	GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat[3]
References	[1]. B Przewlocka, et al. Analgesic and convulsant effects of guanidinoethylmercaptosuccinic acid (GEMSA)--a potent enkephalin convertase inhibitor. Neuropeptides. Nov-Dec 1986;8(4):359-65.

Density	1.59g/cm3
Boiling Point	452.9ºC at 760 mmHg
Melting Point	-180ºC (dec.)
Molecular Formula	C₇H₁₃N₃O₄S
Molecular Weight	235.26100
Flash Point	227.7ºC
Exact Mass	235.06300
PSA	161.80000
LogP	0.32150
Index of Refraction	1.637

Hazard Codes	Xn
Safety Phrases	22-24/25
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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