77482-44-1
77482-44-1 structure
- Name: 2-Guanidinoethylmercaptosuccinic Acid
- Chemical Name: 2-[2-(diaminomethylideneamino)ethylsulfanyl]butanedioic acid
- CAS Number: 77482-44-1
- Molecular Formula: C7H13N3O4S
- Molecular Weight: 235.26100
- Catalog: Research Areas Neurological Disease
- Create Date: 2016-11-14 16:30:29
- Modify Date: 2025-08-25 22:32:18
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GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].
| Name | 2-[2-(diaminomethylideneamino)ethylsulfanyl]butanedioic acid |
|---|---|
| Synonyms |
(2-guanidinoethylmercapto)succinic
DL-guanidinoethylmercaptosuccinic acid 2-(2-guanidinoethylthio) succinic acid 2-guanidinoethylmercaptosuccinic acid gemsa 2-[(2-carbamimidamidoethyl)sulfanyl]succinic acid Guanidinoethyl-Mercaptosuccinic Acid |
| Description | GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1]. |
|---|---|
| Related Catalog | |
| Target |
Encephalin convertase, Ki 值为8.8 nM. |
| In Vitro | GEMSA inhibits the activation of TAFI and porcine CBB[1]. GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin[1]. GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC50 values of 0.34 μM, 100μM, 115 μM, 90 μM respectively[1][2]. |
| In Vivo | GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat[3] |
| References |
| Density | 1.59g/cm3 |
|---|---|
| Boiling Point | 452.9ºC at 760 mmHg |
| Melting Point | -180ºC (dec.) |
| Molecular Formula | C7H13N3O4S |
| Molecular Weight | 235.26100 |
| Flash Point | 227.7ºC |
| Exact Mass | 235.06300 |
| PSA | 161.80000 |
| LogP | 0.32150 |
| Index of Refraction | 1.637 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |