85416-73-5

85416-73-5 structure

Name: S-(+)-Rolipram
Chemical Name: (+)-rolipram
CAS Number: 85416-73-5
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.343
Catalog: Biochemical Inhibitor Metabolism PDE inhibitor
Create Date: 2018-06-12 14:26:08
Modify Date: 2024-01-02 09:56:42
(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.Target: PDE4B; PDE4DRolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2].

Name	(+)-rolipram
Synonyms	(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone S2127_Selleck (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 1oyn S- (+)-Rolipram 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- S-(+)-Rolipram (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (-)-rolipram 1xn0 (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (+)-rolipram (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)- (S)-(+)-Rolipram

Description	(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.Target: PDE4B; PDE4DRolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44. [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98. [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

Density	1.2±0.1 g/cm3
Boiling Point	472.7±45.0 °C at 760 mmHg
Melting Point	133-136ºC
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.343
Flash Point	239.7±28.7 °C
Exact Mass	275.152130
PSA	47.56000
LogP	1.43
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.552
Storage condition	Store at RT

HS Code	2933790090

Precursor 5
1001860-35-0 137-43-9 67387-76-2 621-59-0
141099-44-7
DownStream 0

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

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