83898-65-1
83898-65-1 structure
- Name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one maleate
- Chemical Name: domperidone maleate
- CAS Number: 83898-65-1
- Molecular Formula: C26H28ClN5O6
- Molecular Weight: 541.98300
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2018-07-26 08:41:35
- Modify Date: 2025-08-27 22:33:13
-
Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
| Name | domperidone maleate |
|---|---|
| Synonyms |
(Z)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Domperidone (TN) Prestwick-06G02 5-Chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one maleate Domperidone Maleate |
| Description | Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Cardiac Na+ channels are common targets of therapeutics inducing cardiotoxicity[3]. Domperidone monomaleate (0-1000 μM) displays concentration- and state-dependent inhibitory of Nav1.5 in Human embryonic kidney HEK293 cells[3]. Domperidone monomaleate (0, 10, 100 μM) displays tonic and use-dependent block to Na currents in rat cardiomyocytes with a IC50 of 312 μM[3]. |
| In Vivo | Unlike Metoclopramide, Domperidone monomaleate does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier[1]. Domperidone monomaleate acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported[2]. |
| References |
[2]. Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461. |
| Molecular Formula | C26H28ClN5O6 |
|---|---|
| Molecular Weight | 541.98300 |
| Exact Mass | 541.17300 |
| PSA | 153.42000 |
| LogP | 3.00290 |
| HS Code | 2942000000 |
|---|
| HS Code | 2942000000 |
|---|